CACTUS: INTEGRATING CLONAL ARCHITECTURE WITH GENOMIC CLUSTERING AND TRANSCRIPTOME PROFILING OF SINGLE TUMOR CELLS

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Abstract Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity.Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells.The confidence of the cell-to-clone mapping can b

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EDI electron time-of-flight measurements on Equator-S

We present the first electron time-of-flight measurements obtained with the Electron Drift Instrument (EDI) on Equator-S.These measurements are made possible by amplitude-modulation and coding of ellakai the emitted electron beams and correlation with the signal from the returning electrons.The purpose of the time-of-flight measurements is twofold.

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Relationship between balance and gait in children with a risk of developmental coordination disorders and their typically developing peers

Background: Developmental coordination disorder (DCD), also known as developmental dyspraxia, is a chronic neurological disorder beginning in childhood, that can affect planning of movements and coordination.Balance dysfunction is one of the most common sensorimotor impairments observed among children with DCD, which may have influence on daily liv

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Multi-constraint non-negative matrix factorization for community detection: orthogonal regular sparse constraint non-negative matrix factorization

Abstract Community detection is an important method to analyze the characteristics and structure of community networks, which can excavate the potential links between nodes and further discover subgroups from complex networks.However, most of the existing methods only unilaterally consider the direct link topology without comprehensively considerin

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